All Pandora S Box Effects In The Binding Of Isaac

Pandora’s Box is an Active Item that can potentially save a dying run or put the player over the edge on a thriving run. Based on what floor it’s used on, Pandora’s Box will gift the player a number of different things, then disappear.

• Basement, Cellar, Burning Basement, Downpour, Dross First Floor - Two soul heartsSecond Floor - Two bombs and two keysCaves, Catacombs, Flooded Caves, Mines, AshpitFirst Floor - One Boss Room itemSecond Floor - One Boss Room item and two soul heartsDepths, Necropolis, Dank Depths, Mausoleum, GehennaFirst Floor - Four soul heartsSecond Floor - 20 coinsWomb, Utero, Scarred Womb, CorpseFirst Floor - Two Boss Room itemsSecond Floor - The BibleCathedralOne Angel Room item and one eternal heartSheolOne Devil Room item and one black heartThe ChestOne pennyThe Dark RoomIn Afterbirth+, unlocks the Moving Box item. Without Afterbirth+, does nothing.??? (AKA the Blue Womb)NothingThe VoidNothingFinal Chapter (After the ascent)The Red Key

Note: Pandora’s Box will treat XL floors as if they were the first floor of that area. Also, be careful when using the ? Card. Should you use the ? Card in Afterbirth, it will consume both the card and Pandora’s Box without giving you anything. But in Repentance, it will work, giving you the item(s) from Pandora’s Box without consuming the Active Item itself.

• First Floor - Two soul heartsSecond Floor - Two bombs and two keys

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